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Web-based tools
(Lange lab developments)

BioPathAt
Biochemical pathway maps for integrative analysis of post-genomic data sets

MGR
Genome and transcriptome database for members of the mint family

Spektraris
Accurate mass - time tag (AMT) and NMR library for plant natural products

Research infrastructure

M.J. Murdock Metabolomics Laboratory
Analytical center for metabolomics research

 

 

 

The Lange laboratory investigates the biosynthesis of plant natural products (with an emphasis on terpenoids) using functional genomics and systems biology approaches. We are developing mathematical models to quantitatively describe the regulation of metabolic pathways. Our models enable knowledge-based pathway improvements by breeding or metabolic engineering.

We are particularly interested in understanding metabolism in specialized plant cell types, which are responsible for the synthesis of essential oils, oleoresins, and pharmaceutically relevant natural products.

Group Meetings
Friday, Nov. 4, 2016
Friday, Nov. 18, 2016

Terpenoid Biosynthesis in Arabidopsis, Mint, Pine and Tomato............................................1:00 to 3:00 PM
Terpenoid Natural Products Biosynthesis and Imaging Enzyme Structure-Function..............3:00 to 4:00 PM

Lab Seminar
Friday, September 30, 2016
Dunja Samec
......................................................................................................................1:00 to 2:00 PM

Group members (September 23, 2016)

Back row, left to right:
Jordan Zager, Kellen Mayes, Fima Inabuy.

Front row, left to right:
Mark Lange, Iris Lange, Narayanan Srividya, Amber Parrish, Dunja Samec, Sean Johnson, Brenton Poirier.

Not on photo:
Sophiya Chayka, Richard Schumaker.

..

..Last updated:
November 22, 2016

Lange Laboratory News:

2016 (November 18)
Our paper reporting on the identification and localization of specialized metabolites in Tripterygium roots is published online in Plant Physiology (WebLink to article).

2016 (November 17)
Our collaborative efforts, with the Vining and Croteau laboratories (at OSU and formerly WSU, respectively), result in a publication reporting on the first draft genome from an aromatic plant in Molecular Plant (WebLink to article).

2016 (October 21)
Sean Johnson and Dunja Samec have their last day in the lab. Both are moving on to new positions at Michigan State University (Sean -> Post-Doc) and the
Ruđer Bošković Institute in Croatia (Dunja -> Junior Investigator). We will miss you. Best of luck in your new endeavors!

2016 (September 20)
Mark Lange gives a presentation at the Scientific Affairs Committe Meeting of the Mint Industry Research Council in Orlando, FL.

2016 (Aug. 6-10)
Fima Inabuy and Jordan Zager (graduate students) are presenting posters at the Annual Conference of the Phytochemical Society of North America in Davis, CA. Both of them also received travel awards.

2016 (Aug. 6-10)
Mark Lange gives an invited presentation at the Annual Conference of the Phytochemical Society of North America in Davis, CA.

2016 (Aug. 8)
Mark Lange assumes the office of President-Elect of the Phytochemical Society of North America.

2016 (July 28)
Sean Johnson and Brenton Poirier
defend their dissertations (yes, both on the same day!). Congratulations, Drs. Johnson and Poirier!

2016 (July 9-13)
Dunja Samec (post-doc) presents a poster at the Plant Biology 2016 conference hosted by the
American Society of Plant Biologists in Austin, TX.

2016 (May 2-4)
Mark Lange gives an invited presentation at the
DOE-JGI Microbial & Plant Systems Modulated by Secondary Metabolites Meeting in Walnut Creek, CA.

2016 (April 19-21)
Mark Lange gives an invited presentation at the
International Conference on Synthetic Biology of Natural Products in Beijing, China.

2016 (March 28)
Our review article on designer monoterpene synthases is published online in Methods in Enzymology (WebLink to article).

2016 (March 13-16)
Mark Lange gives an invited presentation at the Annual Conference of the American Chemical Society in San Diego, CA.

2016 (January 31-Feburary 5)
Mark Lange gives an invited presentation at the Gordon Research Conference on Plant Volatiles in Ventura, CA.

2016 (January 22)
Dunja Samec post-doc) is awarded a travel grant to attent the Plant Biology 2016 Conference, hosted by the American Society of Plant Biologists, on July 9-13, 2016, in Austin, TX.

2016 (January 20)
Mark Lange gives an invited presentation at the Annual Conference of the Mint Industry Research Council in Las Vegas, NV.

2016 (January 14)
Mark Lange gives an invited presentation at the Oregon Mint Convention in Gleneden Beach, OR.

2016 (January 8)
Our review article on online resources for gene discovery in medicinal and aromatic plants is published online in Phytochemical Reviews (WebLink to article).

2015 (December 1)
Mark Lange gives an invited lecture at the Washington Mint Convention in Kennewick, WA.

2015 (November 7-8)
Mark Lange gives a plenary lecture at the International Aromatherapy Conference in San Francisco, CA.

2015 (November 6)
Mark Lange gives an invited presentation at Sacramento State University.

2015 (October 15)
Dunja Samec (post-doc) receives the
National Science Award from the Republic of Croatia (highest scientific honor for Junior Researchers in Dunja's home country). On the photo below she is flanked by Josip Leko, President of Croatian Parliament (right), and Vedran Mornar, Minister of Science (left). Congratulations, Dunja!

2015 (October 7)
Mark Lange gives an overview presentation for the Molecular Plant Sciences graduate program at Washington State University.

2015 (September 18)
Mark Lange gives a presentation at the Scientific Affairs Committe Meeting of the Mint Industry Research Council in Denver, CO.

2015 (September 9-11)
Mark Lange gives an invited presentation at the 2015 Bioflavour Conference in Frankfurt, Germany.

2015 (August 17)
(10th paper published this year)
Our paper reporting on the transcriptional control of isoprenoid biosynthesis in the model plant Arabidopsis is published online in Plant Physiology (WebLink to article).

2015 (August 9-12)
Mark Lange gives an invited presentation at the Annual Conference of the Phytochemical Society of North America in Urbana-Champaign, IL.

2015 (July 23)
Our paper reporting on the ultrastructure of grapefruit peel secretory cavities is published online in International Journal of Plant Sciences (WebLink to article).

2015 (July 4)
Blake Herron, a former student and technician in the Lange laboratory, is getting married. Several members of the team (Amber, Brenton, Fima, Iris, Mark and Sean) are making the trip to beautiful Vail, CO, to be present when Blake and Lauren
(née Schopp) are tying the knot.

2015 (June 26-28)
Fima Inabuy, Dunja Samec and Brenton Poirier are presenting posters at the Annual ASPB Western Regional Conference in Pullman, WA.

2015 (June 11)
Fima Inabuy receives the "Best Poster Award" at the Annual Conference of the American Council for Medicinally Active Plants in Spokane, WA. Congratulations, Fima!

2015 (June 10-11)
Mark Lange and Narayanan Srividya are giving invited presentations, and Fima Inabuy and Dunja Samec are presenting posters, at the Annual Conference of the American Council for Medicinally Active Plants in Spokane, WA.

2015 (June 1-5)
Mark Lange and Narayanan Srividya are giving invited presentations, and Sean Johnson, Brenton Poirier and Jordan Zager are presenting posters, at the Terpnet Conference in Vancouver, Canada.

2015 (May 25)
Our paper reporting on the functional characterization of plant homologues of the Niemann-Pick disease type C1 (NPC1) protein is published online in Planta (WebLink to article).

2015 (April 3)
Mark Lange gives an invited presentation at the Metabolomics Symposium, Waters MS Technology Days, at Iowa State University.2015 (March 22-26)
Narayanan Srividya is organizing a symposium on membrane protein biochemicstry at the National Meeting of the American Chemical Society in Denver, CO.

2015 (March 2)
Our paper reporting on the in-depth analysis of limonene synthase mutants is published online in Proceedings of the National Academies of the USA (WebLink to article).

2015 (Feb. 14)
Our review paper on the utility of metabolomcis databases for natural products research is published online in Frontiers in Bioengineering and Biotechnology (WebLink to article).

2015 (Feb. 10)
A paper from a collaborative effort (Rhee, Stanford; University; Fiehn, UC Davis; Nikolau/Welti/Wurtele, Iowa State University; Sumner, Noble Foundation), which reports on relationships between large-scale gene perturbations and global metabolite profiles is published online in Plant Physiology (WebLink to article).

2015 (Jan. 29)
Mark Lange gives an invited presentation at the School of Molecular Biosciences at WSU.

2015 (Jan. 25)
Our review paper on monoterpene biosynthesis and biotechnology is published online in Advances in Biochemical Engineering and Biotechnology (WebLink to article).

2015 (Jan. 22)
Mark Lange gives an invited presentation at the Annual Conference of the Mint Industry Research Council in Las Vegas, NV.

2015 (Jan. 15)
Our review paper summarizing the current status of knowledge about the evolution of plant secretory structures and terpenoid structueal diversity is published online in Annual Review of Plant Biology (WebLink to article).

2015 (Jan. 8)
Mark Lange gives an invited presentation at the Oregon Mint Convention in Gleneden Beach, OR.