Biology & Mathematics:

Infectious Disease Dynamics

General Research Interests

Our research combines experimental and theoretical techniques to investigate mechanisms in virology, immunology, and infectious disease epidemiology.  We use quantitative methods in conjunction with data in order to predict unforeseen biological mechanisms, determine biologically important rate parameters, and evaluate pathogenic mechanisms that are difficult to test directly.  Our systems biology approach, which couples mathematics with experiments, aims to advance our basic understanding of pathogenic mechanisms and lead to new therapeutic strategies.

Current Projects

We are examining the control of lentiviral infection, including human immunodeficiency virus (HIV) and equine infectious anemia virus (EIAV). We use mathematical and computational models of viral dynamics with clinical and experimental data to elucidate the determinants of virus control and escape. Our long-term goal is to uncover fundamental viral or immune mechanisms and to develop effective vaccine strategies.

Other current projects investigate the epidemic spread of influenza infection as well as viral evolution in bacteriophage populations.

School of Biological Sciences, PO Box 644236, Abelson Hall 312, Washington State University, Pullman WA 99164-4236, 509-335-3553, Contact Us
Department of Mathematics, PO Box 643113, Neill Hall 103, Washington State University, Pullman WA 99164-3113, 509-335-3926, Contact Us