Lecture 6: The bodyís defenses
Reading: Ch. 43; Keywords
Overview
Non-specific
Second line of defense - macrophage
Inflamation
PPT Slide
Focus on immune system (3rd line of defense)
Key features
First the major players: Lymphocytes
The lymphatic system
Two types of immune responses
Humoral immunity: B cells and clonal selection
There are a variety of B cells
One B cell becomes activated and proliferates
Some B cells become plasma cells that secrete antibodies
Some B cells become memory cells
Memory cells function in secondary immune response
Primary and secondary immune responses
Summary
What do antibodies do?
Inactivate antigens
Neutralization
Agglutination of antigen bearing particles
Precipitation of soluble antigens
These mechanisms enhance phagocytosis
Antibodies inactivate antigens
Complement system: Step 1 attachment to pathogen
Step 2: Recruitment of complement proteins
Step 3: Activation
Step 4: pore formation
Cell-mediated
Recall that T cells are the other type of lymphocyte
Cell-mediated response happens at the same time
Macrophage engulfs invader
Antigens from invader are presented on macrophage cell surface
Helper T cells are recruited
Helper T cells proliferate and activate cytotoxic T cells and B cells
T cells infected with HIV
Email: rlee@mail.wsu.edu
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