Gradient between extracellular and intracellular fluid favors loss of K+ from the cell

Negatively charged ions will want to follow to balance the loss of (+) charge, but since the intracellular anions are large molecules like amino acids and proteins, they cannot diffuse out.

Negatively charged ions will want to follow to balance the loss of (+) charge, but since the intracellular anions are large molecules like amino acids and proteins, they cannot diffuse out.