Lab History
New
technological advances led to a more comprehensive understanding
of these
findings, and during the past decade there was a significant increase in
research focused directly on DNA repair and chromatin (Figure 1).
Some of
this renewed interest was the result of an increased understanding of
how
proteins involved in transcription interact with nucleosomes (e.g., see
Meijer
and Smerdon, 1999, BioEssays
21, 596). There is now convincing evidence that
nucleosome modifications and rearrangements are required for
efficient
transcriptional processing of DNA. Since the late 70s, the Smerdon lab has
focused on correlations between DNA damage, DNA repair, gene transcription
and
chromatin structure. Comprehensive reviews on the work done in this lab
can be
found in Smerdon and Conconi (1999)
Prog.
Nucl. Acid Res. Mol. Biol.,
62:227, and Gong et al. (2005) DNA Repair
4:884.
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